… Finally, we discuss the promises and challenges of cytokine and chemokine targeting in …
from targeted cytokine therapeutics [153]. Third, the need for chronic administration of cytokine …

Interleukin-6 (IL-6) is a cytokine, which is involved in innate and acquired immunity, in
neural cell maintenance and in metabolism. IL-6 can be synthesized by many different cells …

… role of the NLRP3 inflammasome and IL-1 cytokines in the formation, progression, and …
cytokines with the pathogenesis of cardiovascular diseases. The future will likely include targeted …

… Toll-like receptor 4 (TLR4) on KCs is one of the direct interacting targets of LPS. Upon
activation, inflammatory cytokines and chemokines attract neutrophils and monocytes to the liver. …

… The intimate but complex involvement of neutrophils in various diseases makes them
exciting targets for therapeutic intervention but also necessitates differentiation of beneficial …

… therapeutic targets and approaches. In this review, both existing and emerging targets, …
In addition to cytokine targets and chemokine targets, several important proteins participate …

… This subsequently leads to the release of inflammatory cytokines (eg, interleukin-1β [IL-1β] …
NF-κB targets include the genes of cytokines, chemokines, various adhesion molecules, cell …

… targeted therapies have been proposed [29]. IL-31, although belonging to the Th2 profile,
induces the production of various inflammatory cytokines … anti-osteoporotic therapies against it. …

… Psoriasis is the first disease to have been successfully treated with therapeutics that directly
block the action of the cytokines of this pathway; in fact, therapeutics that specifically target IL…

… as “cytokine storm”, … cytokines leading to cytokine storm include tumor necrosis factor α
(TNFα), interleukin 6 and 1β (IL-6 and IL-1β) [7]. The high volume of swiftly increasing cytokines …